Education

Ph. D. in Organic/Computational Chemistry

The Ohio State University, Columbus, OH, 2013

B.A. in Chemistry, Minor in Psychology

Ohio Wesleyan University, Delaware, OH, 2008

Research Overview

My current research involves the use of molecular modeling experiments to solve critical issues that threaten the health of populations around the globe. Specifically, combatting the effects of toxic organophosphorus nerve agents. Current efforts involve molecular docking studies examining potential therapeutics towards exposure to toxic organophosphorus nerve agents and towards cancer therapeutics. At The Ohio State University, Marion Campus I am able to expose students at the smaller regional campus to a quality undergraduate research experience. Present and past undergraduate students have presented their research at campus, university, and national forums and have also gone on to attend medical school, nursing school, pharmacy school, graduate school, etc.  As a passionate teacher, I have also pursued interests in chemical education research.  Efforts in this area have included studying factors affecting the implementation of student-centered teaching methods and a novel computational drug design activity for the undergraduate organic chemistry laboratory course.

Publications

Schneider, L.; Ruano, M.; Mackey, C.R.; Spiegel, K.; Bouley, R.A.; *Petreaca, R.; *Yoder, R.J. CNR1 and CNR2 cannabinoid receptor mutations in cancer cells. CIMB. In Press.

Dailey, K.A.; Schneider, L.N.; Petreaca, R.C.; *Yoder, R.J. Molecular docking of danuglipron uncovers potential crossovers between GLP-1R and the endocannabinoid system. MicroPubl Biol. 2025. 
doi: 10.17912/micropub.biology.001690.

Stan, A.; Bosart, K.; Kaur, M.; Vo, M.; Escorcia, W.; Yoder, R.J.; *Bouley, R.A.; *Petreaca, R.C. Detection of driver mutations and genomic signatures in endometrial cancers using artificial intelligence algorithms. PLOS One. 2024, 19 (2), e0299114. 

Frank, L.E.; Koehler, B.R.; Yoder, R.J.; *Bouley, R.A. Testing the Ability of Protein–Protein Docking Programs to Model -Known Complexes: A Project for the Biochemistry Classroom. Journal of Chemical Education. 2023, 100 (10), 3968-3973.

Rasheed, S.; Bouley, R.A.; *Yoder, R.J.; *Petreaca, R.C. Protein methyltransferase arginine 5 (PRMT5) mutations in cancer cells. International Journal of Molecular Science. 2023, 24 (7), 6042

Fundamentals of Chemistry for Today General, Organic, & Biochemistry. Spencer L. Seager, Tiffiny D. Rye-McCurdy, Ryan J. Yoder. Cengage Publishing, Mason, OH. 2024.